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apalutamide will decrease the level or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that happen to be CYP3A4 substrates may lead to reduced publicity to these medications.To see formulary facts initial build